Das Lied ist relativ Gesellschaftskritisch: Kinder, die mit Crack dealen; Teenager, die selbst schon Eltern sind usw. Und verbunden werden sie eben alle dadurch, dass sie einem auf den Weg zu Susan begegnen. Deren Schwester kommt aber nicht vor, zum besseren Verständnis hier mal der Text:

Susan's House

Going over to Susan's House, walking south down Baxter Street. Nothing
Hiding behind this picket fence. There's a crazy old woman smashing bottles
on the sidewalk where her house burned down two years ago. People say
that back then, she really wasn't that crazy.

Going over to Susan's House.
Going over to Susan's House, I can't be alone tonight.

Down by the Doughnut Prince, a 15-year-old boy lies on the sidewalk with
a bullet in his forehead. In a final act of indignity, the paramedics
take off all his clothes for the whole world to see while they put him
in the bag. Meanwhile, an old couple argues inside the 'Queen Bee', the sick fluorescent light shimmering on their skin.

Going over to Susan's House.
Going over to Susan's House, she's gonna make it right.

Take a left down Echo Park,
A kid asks do I want some crack?
TV sets are spewing Baywatch
Through the windows into black.

Here comes a girl with long brown hair, who can't be more than seventeen.
The sucks on a red popsickle as she pushes a baby girl in a pink carriage.
And I'm thinking, 'That must be her sister. That must be her sister, right?'
They go into the seven-eleven and I keep walking, and I keep walking.

Going over to Susan's House.
Going over to Susan's House, I can't be alone tonight.
Going over to Susan's House.